Methyl Isobutyl Ketone (MIBK)

Overview

Methyl Isobutyl Ketone (MIBK, CAS No: 108-10-1), also known as 4-methyl-2-pentanone, is a colorless, moderately volatile liquid with a characteristic ketone odor. This organic compound is a powerful solvent widely used in industrial applications.

MIBK has limited solubility in water but is miscible with most organic solvents. Its moderate evaporation rate and high solvency make it a preferred choice in paints, coatings, pharmaceuticals, and chemical processing industries. Industrial production is typically achieved through the condensation of acetone followed by catalytic hydrogenation, ensuring a purity of ≥99.0%.

Applications

Methyl Isobutyl Ketone has a wide range of industrial and consumer applications:

Technical Specifications

Safety Information

Hazard Symbols and Statements

Flammable Eye and skin irritation Central nervous system effects

Personal Protective Equipment (PPE)

• Chemically resistant gloves (nitrile or neoprene)
• Chemical safety goggles or face shield
• Respirator with organic vapor filter
• Chemically resistant apron or work clothing
• Adequate ventilation or local exhaust system

Storage Conditions

• Store in a cool, well-ventilated area
• Keep away from ignition sources and sparks
• Store separately from oxidizers and strong acids/bases
• Use stainless steel, glass, or suitable plastic (HDPE, PTFE) containers
• Storage temperature: 15-25°C

Firefighting Measures

• Suitable extinguishers: Dry chemical powder, CO₂, alcohol-resistant foam
• Avoid water jets as they may spread the fire
• Act with appropriate protective equipment by trained personnel
• Evacuate the area and call firefighters for large fires

Handling and Storage

Handling

• Ensure containers are tightly sealed during transport
• Label as "Flammable Liquid"
• Ground equipment to prevent static electricity buildup
• Avoid eating, drinking, or smoking during handling
• Use stainless steel containers for large-volume transport

Storage

• Store in stainless steel, glass, or suitable plastic (HDPE, PTFE) containers
• Use explosion-proof electrical systems
• Ensure proper ventilation in storage tanks
• Keep firefighting equipment in storage areas
• Prohibit smoking in storage areas

Spill Response

• Eliminate all ignition sources
• Use chemically resistant clothing and respirator
• Absorb small spills with sand, vermiculite, or other absorbents
• Seek professional help for large spills
• Rinse spill area with large amounts of water

Regulatory Information

GHS Classification

• Flammable Liquid, Category 2
• Skin Irritation, Category 2
• Eye Irritation, Category 2A
• Specific Target Organ Toxicity (Single Exposure), Category 3

Key Regulations

• REACH: Registered
• CLP: Compliant
• OSHA: Subject to Hazard Communication Standard
• NFPA 704: Health 1, Flammability 3, Reactivity 0
• EPA: Classified as a VOC

International Regulations

• European Union: Subject to Directive 2008/58/EC
• USA: Listed on TSCA inventory
• China: Listed on IECSC
• Japan: Listed on ISHL

Environmental Information

Environmental Impact

Methyl Isobutyl Ketone degrades moderately in the atmosphere via photochemical reactions (half-life: 2-5 days). It exhibits mild toxicity to aquatic organisms if released into water bodies. MIBK is biodegradable and does not persist in the environment.

Biodegradation

• Air: Photochemical reactions, half-life 2-5 days
• Water: Degrades via microbial activity within 7-28 days
• Soil: Moderate degradation via microbial activity

Waste Management

• Classified as hazardous waste
• Small quantities can be evaporated in permitted facilities
• Large quantities must be incinerated in licensed hazardous waste facilities
• Dispose of in accordance with local regulations
• Avoid release into sewers

Frequently Asked Questions

How is Methyl Isobutyl Ketone produced?

MIBK is typically produced through the condensation of acetone followed by catalytic hydrogenation. Industrial production involves continuous distillation to ensure high purity.

What is the difference between Methyl Isobutyl Ketone and Methyl Ethyl Ketone?

MIBK (C₆H₁₂O) has a longer alkyl chain than MEK (C₄H₈O), resulting in a higher boiling point and slower evaporation rate. MIBK is a stronger solvent and carries slightly lower toxicity risks.

Does Methyl Isobutyl Ketone damage plastics?

MIBK can dissolve or deform polystyrene, PVC, and some other plastics. Polyethylene and polypropylene are resistant to short-term exposure, but prolonged contact should be avoided.

What is the shelf life of Methyl Isobutyl Ketone?

When stored in tightly sealed containers, MIBK has a shelf life of approximately 2 years. It should be protected from moisture and stored airtight.

What should I do if MIBK comes into contact with skin?

Wash with plenty of water and soap. Prolonged contact may cause dryness or irritation. If irritation persists, seek medical attention. In case of eye contact, rinse with water for at least 15 minutes and consult a doctor.